Harrison has been preferred at openside flanker, with Nathan Hughes on the bench, while Billy Vunipola has proved his fitness to start at number eight.
Mike Brown and Jonny May are left out of the 23-man squad, with Goode, Rokoduguni and Elliot Daly making up an all-new back three and Jonathan Joseph returns at centre.
Head coach Eddie Jones was due to name his side on Thursday, but delayed his decision due to injury concerns.
Saracens’ Vunipola, 24, had been a doubt after suffering a knock in last weekend’s win over South Africa.
“While we were satisfied with last week’s result against South Africa, there was plenty to improve on,” said Jones.
“We want a much more complete performance on Saturday. We want to be in total control of the game and tidy-up the things we didn’t do well enough last weekend.”
Source : Internet